Template:Cholesterol and steroid metabolism enzymes: Difference between revisions

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Cholesterol and steroid metabolism enzymes

Revision as of 00:46, 13 May 2023

Metabolism: lipid metabolism – ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase HMG-CoA synthase (regulated step)
Ketogenesis	HMG-CoA lyase 3-hydroxybutyrate dehydrogenase Thiophorase
To Mevalonic acid	HMG-CoA reductase
To DMAPP	Mevalonate kinase Phosphomevalonate kinase Pyrophosphomevalonate decarboxylase Isopentenyl-diphosphate delta isomerase
Geranyl-	Dimethylallyltranstransferase Geranyl pyrophosphate

To lanosterol	Farnesyl-diphosphate farnesyltransferase Squalene monooxygenase Lanosterol synthase
7-Dehydrocholesterol path	Lanosterol 14α-demethylase Sterol-C5-desaturase-like 7-Dehydrocholesterol reductase
Desmosterol path	24-Dehydrocholesterol reductase

Steroidogenesis

To pregnenolone

Cholesterol side-chain cleavage

To corticosteroids

aldosterone: 18-Hydroxylase

cortisol/cortisone: 17α-Hydroxylase
[[11β-Hydroxysteroid dehydrogenase|11β-HSD]]
- 1
- 2

both: [[3β-Hydroxysteroid dehydrogenase|3β-HSD]]
- 1
- 2
21-Hydroxylase
11β-Hydroxylase

To sex hormones

To androgens	17α-Hydroxylase 17,20-Lyase [[3β-Hydroxysteroid dehydrogenase\|3β-HSD]] [[17β-Hydroxysteroid dehydrogenase\|17β-HSD]] 5α-Reductase 1 2
To estrogens	Aromatase [[17β-Hydroxysteroid dehydrogenase\|17β-HSD]]

Other/ungrouped

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