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alpha>Sarika: Created page with "{{Navbox | name = Nitric oxide signaling modulators | title = Nitric oxide signaling modulators | state = {{{state|..."

2022-12-14T05:05:33Z

Created page with "{{Navbox | name = Nitric oxide signaling modulators | title = Nitric oxide signaling modulators | state = {{{state<includeonly>|..."

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{{Navbox
| name = Nitric oxide signaling modulators
| title = [[Nitric oxide]] [[cell signaling|signaling]] [[receptor modulator|modulator]]s
| state = {{{state<includeonly>|collapsed</includeonly>}}}
| listclass = hlist
| groupstyle = text-align:center;

| group1 = [[Nitric oxide|Forms]]
| list1 =
* [[Nitroxyl|Nitroxyl anion (NO−; oxonitrate(1-), hyponitrite anion)]]
* [[Nitric oxide|Nitric oxide (NO⋅; nitrogen monoxide)]]
* [[Nitrosonium|Nitrosonium (NO+; nitrosyl cation)]]

| group2 = [[Biological target|Target]]s
| list2 = {{Navbox|child
| groupstyle = text-align:center;

| group1 = [[Soluble guanylate cyclase|sGC]]
| list1 =
* ''Activators/stimulators:'' [[Ataciguat]]
* [[BAY 41-2272]]
* [[BAY 41-8543]]
* [[BAY 60-4552]]
* [[BI-703704]]
* [[Cinaciguat|Cinaciguat (BAY 58-2667)]]
* [[GSK-2181236A]]
* [[Praliciguat]]
* [[Riociguat]]
* [[Vericiguat]]

* ''Inhibitors:'' [[1H-(1,2,4)Oxadiazolo(4,3-a)quinoxalin-1-one|ODQ]]

}}

| group3 = [[NO donor]]s ([[prodrug]]s)
| list3 =

* ''[[Nitrate]]s:'' [[Diethylene glycol dinitrate|Diethylene glycol dinitrate (DEGDN)]]
* [[Erythritol tetranitrate|Erythritol tetranitrate (ETN)]]
* [[Ethylene glycol dinitrate|Ethylene glycol dinitrate (EGDN; nitroglycol)]]
* [[Isosorbide mononitrate|Isosorbide mononitrate (ISMN)]]
* [[Isosorbide dinitrate|Isosorbide dinitrate (ISDN)]]
* [[Itramin tosilate]]
* [[Mannitol hexanitrate]]
* [[Naproxcinod|Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)]]
* [[NCX-466]]
* [[NCX-2216]]
* [[NCX-4016]]
* [[NCX 4040]]
* [[NCX-4215]]
* [[Nicorandil]]
* [[Nipradilol|Nipradilol (K-351)]]
* [[Nitrate|Nitrate (NO{{su|b=3|p=−}})]]
* [[Nitroatorvastatin|Nitroatorvastatin (NCX-6560)]]
* [[Nitroflurbiprofen|Nitroflurbiprofen (HCT-1026)]]
* [[Nitrofluvastatin|Nitrofluvastatin]]
* [[Nitroglycerin (drug)|Nitroglycerin (glyceryl trinitrate (GTN))]]
* [[Nitropravastatin|Nitropravastatin (NCX-6550)]]
* [[Pentaerithrityl tetranitrate|Pentaerithrityl tetranitrate (PETN)]]
* [[Propatylnitrate]]
* [[Propylene glycol dinitrate|Propylene glycol dinitrate (PGDN)]]
* [[Sodium trioxodinitrate|Sodium trioxodinitrate (Angeli's salt)]]
* Tenitramine
* [[Trolnitrate]]

* ''[[Nitroso compound]]s/[[nitrite]]s:'' [[Nitrite|Nitrite (NO{{su|b=2|p=−}})]]; ''O-Nitroso compounds ([[alkyl nitrite]]s):'' [[Amyl nitrite|Amyl nitrite (isoamyl nitrite, isopentyl nitrite)]]
* [[Cyclohexyl nitrite]]
* [[Ethyl nitrite]]
* [[Hexyl nitrite]]
* [[Isobutyl nitrite|Isobutyl nitrite (2-methylpropyl nitrite)]]
* [[Isopropyl nitrite]]
* [[Methyl nitrite]]
* [[Butyl nitrite|''n''-Butyl nitrite]]
* [[Pentyl nitrite]]
* [[tert-Butyl nitrite|''tert''-Butyl nitrite]]; ''[[S-Nitrosothiol|S-Nitroso compound]]s (thionitrites):'' [[LA810]]
* [[S-Nitrosoalbumin|S-Nitrosoalbumin (SNALB)]]
* [[S-Nitrosated AR545C]]
* [[S-Nitroso-N-acetylcysteine|S-Nitroso-N-acetylcysteine (SNAC)]]
* [[S-Nitroso-N-acetylpenicillamine|S-Nitroso-N-acetylpenicillamine (SNAP)]]
* [[S-Nitroso-N-valerylpenicillamine|S-Nitroso-N-valerylpenicillamine (SNVP)]]
* [[S-Nitrosocaptopril|S-Nitrosocaptopril (SNO-Cap)]]
* [[S-Nitrosocysteine|S-Nitrosocysteine (SNC, CysNO, SNO-Cys)]]
* [[S-Nitrosodiclofenac]]
* [[S-Nitrosoglutathione|S-Nitrosoglutathione (GSNO, SNOG)]]
* [[S-Nitrosated tissue-type plasminogen activator|SNO-t-PA]]
* [[S-Nitrosated von Willebrand factor|SNO-vWF]]; ''N-Nitroso compounds (e.g., [[nitrosamine]]s):'' [[SIN-1A]]

* ''Nitrosyl compounds:'' ''[[Metal nitrosyl complex]]es:'' [[Roussin's black salt]]
* [[Roussin's red salt]]
* [[Sodium nitroprusside|Sodium nitroprusside (SNP)]]

* ''[[NONOate]]s (diazeniumdiolates):'' [[Diethylamine/NO|Diethylamine/NO (DEA/NO)]]
* [[Diethylenetriamine/NO|Diethylenetriamine/NO (DETA/NO)]]
* [[GLO/NO]]
* [[JS-K]]
* [[Methylamine hexamethylene methylamine/NO|Methylamine hexamethylene methylamine/NO (MAHMA/NO)]]
* [[PROLI/NO]]
* [[Spermine/NO|Spermine/NO (SPER/NO)]]
* [[V-PYRRO/NO]]

* ''Heterocyclic compounds:'' ''[[Furoxan]]s:'' [[Furoxan]]
* [[REC15/2739]]; ''[[Sydnonimine]]s:'' [[Feprosidnine]]
* [[Linsidomine|Linsidomine (SIN-1)]]
* [[Molsidomine|Molsidomine (SIN-10)]]
* [[Sydnonimine]]

* ''Unsorted:'' [[Cimlanod]]
* [[FK-409]]
* [[FR144220]]
* [[FR146881]]
* [[N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide]]

| group4 = [[Enzyme]] ([[Enzyme inhibitor|inhibitor]]s)
| list4 = {{Navbox|child
| groupstyle = text-align:center;

| group1 = [[Nitric oxide synthase|NOS]]
| list1 = {{Navbox|child
| groupstyle = text-align:center;

| group1 = [[NOS1|nNOS]]
| list1 =
* [[3-Bromo-7-nitroindazole]]
* [[3-Chloroindazole]]
* [[3-Chloro-5-nitroindazole]]
* [[5-Nitroindazole]]
* [[6-Nitroindazole]]
* [[7-Nitroindazole]]
* [[A-84643]]
* [[Aminoguanidine|Aminoguanidine (pimagedine)]]
* [[ARL-17477]]
* [[Indazole]]
* [[N5-(1-Iminoethyl)-L-ornithine|N5-(1-Iminoethyl)-L-ornithine (L-NIO)]]
* [[Nω-Methyl-L-arginine|Nω-Methyl-L-arginine (L-NMA)]]
* [[Nω-Propyl-L-arginine|Nω-Propyl-L-arginine (L-NPA)]]
* [[Nitroarginine|Nitroarginine (NNA, NOARG)]]
* [[Pentamidine isethionate]]
* [[1-(2-Trifluoromethylphenyl)imidazole|TRIM]]

| group2 = [[Nitric oxide synthase 2 (inducible)|iNOS]]
| list2 =
* [[1-Amino-2-hydroxyguanidine]]
* [[2-Ethylaminoguanidine]]
* [[2-Iminopiperidine]]
* [[1400W]]
* [[S-aminoethylisothiourea|AEITU]]
* [[Aminoguanidine|Aminoguanidine (pimagedine)]]
* [[2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine|AMT]]
* [[AR-C 102222]]
* [[BYK-191023]]
* [[Canavanine]]
* [[Cindunistat|Cindunistat (SD-6010)]]
* [[S-Ethylisothiourea|EITU]]
* [[S-Isopropylisothiourea|IPTU]]
* [[S-Methylisothiourea|MITU]]
* [[N5-(1-Iminoethyl)-L-ornithine|N5-(1-Iminoethyl)-L-ornithine (L-NIO)]]
* [[N6-(1-Iminoethyl)-L-lysine|N6-(1-Iminoethyl)-L-lysine (L-NIL)]]
* [[Nω-Methyl-L-arginine|Nω-Methyl-L-arginine (L-NMA)]]
* [[Ronopterin|Ronopterin (VAS-203)]]
* [[1-(2-Trifluoromethylphenyl)imidazole|TRIM]]

| group3 = [[Endothelial NOS|eNOS]]
| list3 =
* [[Aminoguanidine|Aminoguanidine (pimagedine)]]
* [[N5-(1-Iminoethyl)-L-ornithine|N5-(1-Iminoethyl)-L-ornithine (L-NIO)]]
* [[Nω-Methyl-L-arginine|Nω-Methyl-L-arginine (L-NMA)]]
* [[Nitroarginine|Nitroarginine (NNA, NOARG)]]

| group4 = Unsorted
| list4 =
* [[Asymmetric dimethylarginine|Asymmetric dimethylarginine (ADMA)]]
* [[CKD-712]]
* [[Guanidinoethyldisulfide|Guanidinoethyldisulfide (GED)]]
* [[GW-273629]]
* [[Indospicine]]
* [[KD-7040]]
* [[Nitroarginine methyl ester|Nitroarginine methyl ester (NAME)]]
* [[NCX-456]]
* [[NXN-462]]
* [[ONO-1714]]
* [[VAS-2381]]

}}

| group2 = [[Nitrate reductase]]
| list2 =

| group3 = [[Arginase]]
| list3 =
* [[2S-Amino-6-boronohexonic acid|ABH]]
* [[Nω-Hydroxy-L-arginine|Nω-Hydroxy-L-arginine (NOHA)]]
* [[chlorogenic acid]]
* [[ginseng]]
* [[epicatechin]]
* [[ornithine]]
* [[norvaline]]
* [[lysine]]
* [[alpha aminoacids]]

| group4 = [[CAMK]]
| list4 =
* [[Calmidazolium]]
* [[W-7 (drug)|W-7]]

| group5 = [[GTP cyclohydrolase I|GTPCH]]
| list5 =

| group6 = [[6-Pyruvoyltetrahydropterin synthase|PTPS]]
| list6 =

| group7 = [[Sepiapterin reductase|SPR]]
| list7 =

}}

| group5 = Others
| list5 =
* ''Precursors:'' [[Arginine|L-Arginine]]
* [[Nω-Hydroxy-L-arginine|Nω-Hydroxy-L-arginine (NOHA)]]

* ''Cofactors:'' [[Nicotinamide adenine dinucleotide phosphate|NADPH]]
* [[Flavin adenine dinucleotide|FAD]]
* [[Flavin mononucleotide|FMN]]
* [[Heme]]
* [[Tetrahydrobiopterin|BH4]]
* [[Calmodulin|CaM]]
* [[Oxygen|O2]]
* [[Calcium|Ca2+]]

* ''Indirect/downstream NO modulators:'' [[ACE inhibitor]]s/[[Angiotensin II receptor antagonist|AT-II receptor antagonist]]s (e.g., [[captopril]], [[losartan]])
* [[Endothelin receptor antagonist|ETB receptor antagonist]]s (e.g., [[bosentan]])
* [[L-Type calcium channel|L-Type calcium channel]] [[calcium channel blocker|blocker]]s (e.g., [[dihydropyridine]]s: [[nifedipine]])
* [[Nebivolol]] ([[beta blocker]])
* [[PDE5 inhibitor]]s (e.g., [[sildenafil]])
* non-selective PDE inhibitors (e.g., [[caffeine]])
* PDE9 inhibitors (e.g., [[paraxanthine]])
* cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
* [[Statin]]s (e.g., [[simvastatin]])

| below = '''''See also:''' [[Template:Receptor modulators|Receptor/signaling modulators]]''

}}<noinclude>
{{collapsible option}}
[[Category:Drug templates by receptor, channel, or pump]]
</noinclude>[[Category: Templates Vigyan Ready]]

Template:Nitric oxide signaling modulators - Revision history

Indicwiki: 1 revision imported from :alpha:Template:Nitric_oxide_signaling_modulators

alpha>Sarika: Created page with "{{Navbox | name = Nitric oxide signaling modulators | title = Nitric oxide signaling modulators | state = {{{state|..."