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{{Navbox
| name = GABA receptor modulators
| title = [[GABA receptor|{{abbr|GABA|γ-Aminobutyric acid}} receptor]] [[receptor modulator|modulator]]s
| state = {{{state<includeonly>|collapsed</includeonly>}}}
| bodyclass = hlist
| groupstyle = text-align:center;

| group1 = [[Ionotropic GABA receptors|Ionotropic]]
| list1 = {{Navbox|subgroup
| groupstyle = text-align:center
| groupwidth = 5em

| group1 = {{abbrlink|GABAA|γ-Aminobutyric acid A receptor}}
| list1 =
* ''Agonists:'' [[Catechin|(+)-Catechin]]
* [[Bamaluzole]]
* [[Barbiturate]]s (e.g., [[phenobarbital]])
* [[Beta-Alanine]]
* [[BL-1020]]
* [[5-Aminovaleric acid|DAVA]]
* [[Dihydromuscimol]]
* [[gamma-Aminobutyric acid|GABA]]
* [[Gabamide]]
* [[GABOB]]
* [[Gaboxadol|Gaboxadol (THIP)]]
* [[Homotaurine|Homotaurine (tramiprosate, 3-APS)]]
* [[Ibotenic acid]]
* [[iso-THAZ]]
* [[iso-THIP]]
* [[Isoguvacine]]
* [[Isomuscimol]]
* [[Isonipecotic acid]]
* [[Kojic amine]]
* [[L-838,417]]
* [[Lignan]]s (e.g., [[honokiol]])
* [[Methylglyoxal]]
* [[Monastrol]]
* [[Muscimol]]
* [[Nefiracetam]]
* [[Neuroactive steroid]]s (e.g., [[allopregnanolone]])
* [[Org 20599]]
* [[PF-6372865]]
* [[Phenibut]]
* [[Picamilon]]
* [[Piperidine-4-sulfonic acid|P4S]]
* [[Progabide]]
* [[Propofol]]
* [[Quisqualamine]]
* [[SL-75102]]
* [[Taurine]]
* [[trans-4-Aminocrotonic acid|TACA]]
* [[trans-2-(Aminomethyl)cyclopropanecarboxylic acid|TAMP]]
* [[Terpenoid]]s (e.g., [[borneol]])
* [[Thiomuscimol]]
* [[Tolgabide]]
* [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]]

* ''Positive modulators (abridged; see [[Template:GABAAR PAMs|here]] for a full list):'' [[α-Ethyl-α-methylthiobutyrolactone|α-EMTBL]]
* [[Alcohol (chemistry)|Alcohol]]s (e.g., [[alcohol (drug)|drinking alcohol]], [[tert-Amyl alcohol|2M2B]])
* [[Anabolic steroid]]s
* [[Avermectin]]s (e.g., [[ivermectin]])
* [[Barbiturate]]s (e.g., [[phenobarbital]])
* [[Benzodiazepine]]s (e.g., [[diazepam]])
* [[Bromide]] compounds (e.g., [[potassium bromide]])
* [[Carbamate]]s (e.g., [[meprobamate]])
* [[Carbamazepine]]
* [[Chloralose]]
* [[Chlormezanone]]
* [[Clomethiazole]]
* [[Dihydroergoline]]s (e.g., [[ergoloid|ergoloid (dihydroergotoxine)]])
* [[Etazepine]]
* [[Etifoxine]]
* [[Fenamate]]s (e.g., [[mefenamic acid]])
* [[Flavonoid]]s (e.g., [[apigenin]], [[hispidulin]])
* [[Fluoxetine]]
* [[Flupirtine]]
* [[Imidazole]]s (e.g., [[etomidate]])
* [[Kava]] constituents (e.g., [[kavain]])
* [[Lanthanum]]
* [[Loreclezole]]
* [[Monastrol]]
* [[Neuroactive steroid]]s (e.g., [[allopregnanolone]], [[cholesterol]], [[THDOC]])
* [[Niacin (substance)|Niacin]]
* [[Niacinamide]]
* [[Nonbenzodiazepine]]s (e.g., [[β-carboline]]s (e.g., [[abecarnil]]), [[cyclopyrrolone]]s (e.g., [[zopiclone]]), [[imidazopyridine]]s (e.g., [[zolpidem]]), [[pyrazolopyrimidine]]s (e.g., [[zaleplon]]))
* [[Norfluoxetine]]
* [[Petrichloral]]
* [[Phenol]]s (e.g., [[propofol]])
* [[Phenytoin]]
* [[Piperidinedione]]s (e.g., [[glutethimide]])
* [[Propanidid]]
* [[Pyrazolopyridine]]s (e.g., [[etazolate]])
* [[Quinazolinone]]s (e.g., [[methaqualone]])
* [[Retigabine|Retigabine (ezogabine)]]
* [[ROD-188]]
* [[Scutellaria|Skullcap]] constituents (e.g., [[baicalin]])
* [[Stiripentol]]
* [[Sulfonylalkane]]s (e.g., [[sulfonmethane|sulfonmethane (sulfonal)]])
* [[Topiramate]]
* [[Valerian (herb)|Valerian]] constituents (e.g., [[valerenic acid]])
* [[Volatility (chemistry)|Volatiles]]/[[gas]]es (e.g., [[chloral hydrate]], [[chloroform]], [[diethyl ether]], [[paraldehyde]], [[sevoflurane]])

* ''Antagonists:'' [[Bicuculline]]
* [[Coriamyrtin]]
* [[Dihydrosecurinine]]
* [[Gabazine|Gabazine (SR-95531)]]
* [[Hydrastine]]
* [[Hyenanchin|Hyenachin (mellitoxin)]]
* [[PHP-501]]
* [[Pitrazepin]]
* [[Securinine]]
* [[Sinomenine]]
* [[SR-42641]]
* [[SR-95103]]
* [[Thiocolchicoside]]
* [[Tutin (toxin)|Tutin]]

* ''Negative modulators:'' [[5-Ethyl-5-(1,3-dimethylbut-1'-enyl)barbituric acid|1,3M1B]]
* [[5-Ethyl-5-(3-methylbut-2'-enyl)barbituric acid|3M2B]]
* [[11-Ketoprogesterone]]
* [[17-Phenylandrostenol]]
* [[α5IA|α5IA (LS-193,268)]]
* [[Butyl β-carboline-3-carboxylate|β-CCB]]
* [[Ethyl β-carboline-3-carboxylate|β-CCE]]
* [[Methyl β-carboline-3-carboxylate|β-CCM]]
* [[Propyl β-carboline-3-carboxylate|β-CCP]]
* [[β-Ethyl-β-methyl-γ-butyrolactone|β-EMGBL]]
* [[Anabolic steroid]]s
* [[Amiloride]]
* [[Anisatin]]
* [[β-Lactam]]s (e.g., [[penicillin]]s, [[cephalosporin]]s, [[carbapenem]]s)
* [[Basmisanil]]
* [[Bemegride]]
* [[Bicyclic phosphate]]s ([[TBPS]], [[TBPO]], [[IPTBO]])
* [[BIDN]]
* [[Bilobalide]]
* [[Bupropion]]
* [[5-(2-Cyclohexylideneethyl)-5-ethylbarbituric acid|CHEB]]
* [[Chlorophenylsilatrane]]
* [[Cicutoxin]]
* [[Cloflubicyne]]
* [[Cyclothiazide]]
* [[Dehydroepiandrosterone|DHEA]]
* [[Dehydroepiandrosterone sulfate|DHEA-S]]
* [[Dieldrin]]
* [[(+)-5-(1,3-Dimethylbutyl)-5-ethylbarbituric acid|(+)-DMBB]]
* [[DMCM]]
* [[5,7-Dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one|DMPC]]
* [[EBOB]]
* [[Etbicyphat]]
* [[FG-7142|FG-7142 (ZK-31906)]]
* [[Fiprole]]s (e.g., [[fipronil]])
* [[Flavonoid]]s (e.g., [[amentoflavone]], [[oroxylin A]])
* [[Flumazenil]]
* [[Fluoroquinolone]]s (e.g., [[ciprofloxacin]])
* [[Flurothyl]]
* [[Furosemide]]
* [[Golexanolone]]
* [[Iomazenil (123I)|Iomazenil (123I)]]
* [[IPTBO]]
* [[Isopregnanolone|Isopregnanolone (sepranolone)]]
* [[L-655,708]]
* [[Laudanosine]]
* [[Leptazol]]
* [[Lindane]]
* [[MaxiPost]]
* [[Morphine]]
* [[Morphine-3-glucuronide]]
* [[MRK-016]]
* [[Naloxone]]
* [[Naltrexone]]
* [[Nicardipine]]
* [[Nonsteroidal antiandrogen]]s (e.g., [[apalutamide]], [[bicalutamide]], [[enzalutamide]], [[flutamide]], [[nilutamide]])
* [[Oenanthotoxin]]
* [[Pentylenetetrazol|Pentylenetetrazol (pentetrazol)]]
* [[Phenylsilatrane]]
* [[Picrotoxin]] (i.e., [[picrotin]], [[picrotoxinin]] and [[dihydropicrotoxinin]])
* [[Pregnenolone sulfate]]
* [[Propybicyphat]]
* [[PWZ-029]]
* [[Radequinil]]
* [[Ro 15-4513]]
* [[Ro 19-4603]]
* [[RO4882224]]
* [[RO4938581]]
* [[Sarmazenil]]
* [[Salicylidene salicylhydrazide|SCS]]
* [[Suritozole]]
* [[TB-21007]]
* [[t-Butylbicycloorthobenzoate|TBOB]]
* [[TBPS]]
* [[TCS-1105]]
* [[Terbequinil]]
* [[Tetramethylenedisulfotetramine|TETS]]
* [[Thujone]]
* [[U-93631]]
* [[Zinc]]
* [[ZK-93426]]

| group2 = {{abbrlink|GABAA-ρ|γ-Aminobutyric acid A-rho receptor}}
| list2 =
* ''Agonists:'' [[BL-1020]]
* [[(Z)-4-Amino-2-butenoic acid|CACA]]
* [[(+)-cis-2-Aminomethylcyclopropane carboxylic acid|CAMP]]
* [[Homohypotaurine]]
* [[gamma-Aminobutyric acid|GABA]]
* [[GABOB]]
* [[Ibotenic acid]]
* [[Isoguvacine]]
* [[Muscimol]]
* [[N4-Chloroacetylcytosine arabinoside|''N''4-Chloroacetylcytosine arabinoside]]
* [[Picamilon]]
* [[Progabide]]
* [[trans-4-Aminocrotonic acid|TACA]]
* [[trans-2-(Aminomethyl)cyclopropanecarboxylic acid|TAMP]]
* [[Thiomuscimol]]
* [[Tolgabide]]

* ''Positive modulators:'' [[Allopregnanolone]]
* [[Alphaxolone]]
* [[Allotetrahydrodeoxycorticosterone|ATHDOC]]
* [[Lanthanide]]s

* ''Antagonists:'' [[(S)-4-Amino-2-methylbutanoic acid|(S)-2-MeGABA]]
* [[(S)-(4-Aminocyclopent-1-enyl)butylphosphinic acid|(S)-4-ACPBPA]]
* [[(S)-4-Aminocyclopent-1-ene-1-carboxylic acid|(S)-4-ACPCA]]
* [[trans-4-Amino-2-methylbut-2-enoic acid|2-MeTACA]]
* [[3-Aminopropyl(methyl)phosphinic acid|3-APMPA]]
* [[4-Aminocyclopent-1-enecarboxamide|4-ACPAM]]
* [[4-Guanidinobutanoic acid|4-GBA]]
* [[cis-(3-Aminocyclopentyl)butylphosphinic acid|''cis''-3-ACPBPA]]
* [[CGP-36742|CGP-36742 (SGS-742)]]
* [[5-Aminovaleric acid|DAVA]]
* [[Gabazine|Gabazine (SR-95531)]]
* [[Gaboxadol|Gaboxadol (THIP)]]
* [[Imidazole-4-acetic acid|I4AA]]
* [[Isonipecotic acid]]
* [[Loreclezole]]
* [[4-(Piperidin-4-yl)methylphosphinic acid|P4MPA]]
* [[Piperidine-4-sulfonic acid|P4S]]
* [[SKF-97541]]
* [[SR-95318]]
* [[SR-95813]]
* [[(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid|TPMPA]]
* [[trans-(3-Aminocyclopentyl)butylphosphinic acid|''trans''-3-ACPBPA]]
* [[(Z)-3-((Aminoiminomethyl)thio)prop-2-enoic acid|ZAPA]]

* ''Negative modulators:'' [[5α-Dihydroprogesterone]]
* [[Bilobalide]]
* [[Loreclezole]]
* [[Picrotoxin]] ([[picrotin]], [[picrotoxinin]])
* [[Pregnanolone]]
* [[ROD-188]]
* [[Tetrahydrodeoxycorticosterone|THDOC]]
* [[Zinc]]

}}

| group2 = [[Metabotropic]]
| list2 = {{Navbox|subgroup
| groupstyle = text-align:center;
| groupwidth = 5em

| group1 = {{abbrlink|GABAB|γ-Aminobutyric acid B receptor}}
| list1 =
* ''Agonists:'' [[1,4-Butanediol]]
* [[3-APPA]]
* [[4-Fluorophenibut]]
* [[Aceburic acid]]
* [[Arbaclofen]]
* [[Arbaclofen placarbil]]
* [[Baclofen]]
* [[BL-1020]]
* [[gamma-Aminobutyric acid|GABA]]
* [[Gabamide]]
* [[GABOB]]
* [[gamma-Butyrolactone|GBL]]
* [[gamma-Hydroxybutyric acid|GHB]]
* [[γ-Hydroxybutaldehyde|GHBAL]]
* [[gamma-Hydroxyvaleric acid|GHV]]
* [[gamma-Valerolactone|GVL]]
* [[Isovaline]]
* [[Lesogaberan]]
* [[Phenibut]]
* [[Picamilon]]
* [[Progabide]]
* [[Sodium oxybate]]
* [[SKF-97,541]]
* [[SL 75102]]
* [[Tolgabide]]
* [[Tolibut]]

* ''Positive modulators:'' [[ADX-71441]]
* [[BHF-177]]
* [[BHFF]]
* [[BSPP (drug)|BSPP]]
* [[CGP-7930]]
* [[CGP-13501]]
* [[GS-39783]]
* [[rac-BHFF]]
* [[KK-92A]]

* ''Antagonists:'' [[2-Hydroxysaclofen]]
* [[CGP-35348]]
* [[CGP-46381]]
* [[CGP-52432]]
* [[CGP-54626]]
* [[CGP-55845]]
* [[CGP-64213]]
* [[5-Aminovaleric acid|DAVA]]
* [[Homotaurine|Homotaurine (tramiprosate, 3-APS)]]
* [[Phaclofen]]
* [[Saclofen]]
* [[SCH-50911]]
* [[SKF-97541]]

* ''Negative modulators:'' [[Compound 14]]

}}

| below =
;See also
: ''[[Template:Receptor modulators|Receptor/signaling modulators]] ''
: ''[[Template:GABAA receptor positive modulators|GABAA receptor positive modulators]] ''
: ''[[Template:GABA metabolism and transport modulators|GABA metabolism/transport modulators]] ''

}}<noinclude>
{{collapsible option}}
[[Category:Drug templates by receptor, channel, or pump]]
</noinclude>

← Older revision	Revision as of 14:52, 16 February 2023
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Template:GABA receptor modulators - Revision history

Indicwiki: 1 revision imported from :alpha:Template:GABA_receptor_modulators

Admin: 1 revision imported

wikipedia>The Banner at 22:19, 24 August 2022